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2010 Gage Conference Session Details
| Wednesday 14th April 2010 | |
| 09:30 | Registration opens |
| 10:30 | Morning tea / Registration |
| 11:00 | Welcome and Gage Lecture – Chair: Angela Dulhunty |
| 11:00 | Welcome |
| 11:15 | David Allen. Duchenne muscular dystrophy - what is the primary pathology? |
| 12:15 | Close |
| 12:15 | Lunch |
| 13:30 | Dystrophic Muscle diseases – Chair: Kathryn North |
| 13:30 | M. Grounds: Strategies to reduce necrosis of dystrophic muscle in the mdx mouse model of DMD |
| 14:00 | S.T. Cooper: Muscle damage, calcium and muscular dystrophy: what we are learning about skeletal muscle membrane repair |
| 14:30 | F.J. Evesson: Studying dysferlin protein behaviour to understand muscular dystrophy |
| 14:45 | L.B. Waddell: Improving diagnosis of rare muscular dystrophies |
| 15:00 | Close |
| 15:00 | Afternoon Tea / Posters |
| 15:00 | Posters |
| 16:00 | Muscle atrophy and diseases – Chair: Miranda Grounds |
| 16:00 | N.F. Clarke: Abnormal sarcoplasmic reticulum structure and function in skeletal myopathies due to mutations in sarcomeric proteins |
| 16:30 | T. Shavlakadze: Age-related skeletal muscle wasting (sarcopenia): muscle innervation, myogenic stem cells and IGF-1 |
| 17:00 | G. Ravenscroft: A transgenic mouse model of severe skeletal muscle actin disease |
| 17:15 | J.T. Seto: Enhanced exercise training response with α-actinin-3 deficiency is associated with calcineurin/NFAT activation |
| 17:30 | Dinner |
| 19:00 | Muscle atrophy and diseases – Chair: Gordon Lynch |
| 19:00 | P.G. Arthur: Could protein thiol oxidation drive muscle wasting during oxidative stress? |
| 19:30 | P. Gregorevic: Exploring the role of microRNAs in skeletal muscle growth and wasting |
| 20:00 | V.C. Foletta: NDRG2 interacts with atrogin-1. A novel role for NDRG2 in skeletal muscle atrophy? |
| 20:15 | R. Meech: Homeobox factors and MyoD are novel effectors of wnt signaling in muscle stem cells |
| 20:30 | Social Mixer |
| Thursday 15th April 2010 | |
| 07:30 | Breakfast |
| 08:30 | Signalling in skeletal muscle – Chair: Graham Lamb |
| 08:30 | B.S. Launikonis: Mapping Ca2+ movements across the tubular (t-) system and sarcoplasmic reticulum membranes to derive changes in associated proteins functional states during Ca2+ release |
| 09:00 | G.S. Lynch: Identifying novel roles for β-adrenoceptor signalling in skeletal muscle: implications for muscle growth, adaptation, regeneration and plasticity |
| 09:30 | T.L. Dutka: Peroxynitrite modification of the contractile apparatus of mechanically-skinned muscle fibres of the rat |
| 09:45 | T.F. Reardon: Increased intracellular iron in skeletal muscle cells can accelerate the production of superoxide |
| 10:00 | J.N. Edwards: Longitudinal tubules compensate for action potential failure in transverse tubules during excitation in mammalian skeletal muscle |
| 10:15 | A.J. Bakker: The effect of selenium on intracellular Ca2+ signalling and force production in skeletal muscle preparations of the mouse |
| 10:30 | Close |
| 10:39 | Morning tea |
| 11:00 | Muscle as a metabolic organ – Chair: Peter Arthur |
| 11:00 | K.N. North: ACTN3 genotype is a determinant of normal variation in muscle metabolism and calcium handling |
| 11:30 | Aaron Russell. PGC-1α regulates protein synthesis |
| 12:00 | K.T. Murphy: Antibody-directed myostatin inhibition in aged mice reveals novel roles for myostatin signaling in skeletal muscle metabolism and apoptosis |
| 12:15 | J. Nielsen: Intramyofibrillar glycogen is decreased following immobilization of young and old men |
| 12:30 | Close |
| 12:30 | Lunch |
| 13:30 | Ca release mechanisms and EC Coupling – Chair: Derek Laver |
| 13:30 | N.F. Clarke: The histological phenotypes associated with RYR1 mutations broaden to include centronuclear myopathy and congenital fibre type disproportion |
| 13:45 | A.F. Dulhunty: An overview of some recent advances in understanding skeletal muscle excitation-contraction coupling |
| 14:15 | M. Casarotto: The SH3 domain of the DHPR β1a-subunit: the missing link in skeletal muscle excitation contraction coupling |
| 14:45 | N. Beard: Triadin and Junctin – not just luminal anchoring proteins |
| 15:15 | S.P. Cairns: Ionic determinants of action potential threshold during electric field stimulation in mammalian skeletal muscle: a modelling approach |
| 15:30 | Close |
| 15:30 | Afternoon Tea / Posters |
| 16:30 | Muscle excitability and remodelling – Chair: David Allen |
| 16:30 | Graham Lamb. Muscle excitability and dysfunction |
| 17:00 | B.A. Cromer: Modulation of skeletal muscle ClC-1 chloride channels by ATP and acidosis - a regulator of excitability during fatigue? |
| 17:30 | R.M. Murphy: The deconstructing and reconstructing capabilities of calpains in skeletal muscle |
| 18:00 | N.T. Larkins: Properties of heat shock proteins in skeletal muscle |
| 18:15 | J.P. Mollica: Properties of m-calpain in rat slow- and fast-twitch skeletal muscle |
| 18:30 | Close |
| 18:30 | BBQ Dinner - to 21:00 |
| Friday 16th April 2010 | |
| 07:30 | Breakfast |
| 09:00 | EC coupling in the heart – Chair: Lea Delbridge |
| 09:00 | C. Soeller: Novel imaging methods to probe excitation-contraction coupling protein distribution in cardiac muscle |
| 09:30 | D. Laver: Changes in cardiac RyR function due to adrenergic stimulation of the heart |
| 10:00 | T.R. Shannon: Investigation and characterizaton of β-adreneric CaMKII-dependent diastolic calcium release in cardiac myocytes |
| 10:30 | Close |
| 10:30 | Morning tea |
| 11:00 | Ischaemia and cardiac disease |
| 11:00 | Lea Delbridge. Inherited cardiomyopathy has its origins in early myocyte loss |
| 11:30 | David Saint. Cardiac reperfusion injury |
| 12:00 | S.M. Weiss: A potential treatment for ischaemia-reperfusion injury in skeletal muscle |
| 12:15 | G. S. Posterino: Intrauterine growth restriction alters troponin expression and cardiac contractility |
| 12:30 | Close |
| 12:30 | Lunch |
| 13:30 | Pacemaker and muscle stretch – Chair: David Saint |
| 13:30 | Y.K. Ju: The expression of functional inositol 1,4,5-trisphosphate receptors in mouse sino-atrial node |
| 14:00 | M. Ward: Stretch-dependent changes in [Ca2+]i and [Na+]i in rat RV trabeculae |
| 14:30 | Jie Liu. Firing of the mouse SA node depends on PKA-dependent signalling |
| 14:45 | Closing Comments – Angela Dulhunty |
| 15:00 | Close |
| 15:00 | Depart |
| Posters | |
| 1 | L.M. Edwards: The reproducibility of 31P magnetic resonance measurements of skeletal muscle metabolites in trained men |
| 2 | T.R. Cully: Store-operated Ca2+ entry in intact wt and mdx mouse skeletal muscle fibres |
| 3 | C.R.H. Lamboley: The resting concentration of Ca2+ in the sarcoplasmic reticulum (SR) and evidence for a pH gradient across the SR membrane of frog skeletal muscle |
| 4 | Y. Karunasekara: Interactions of the skeletal dihydropyridine receptor Ca2+ channel β subunit with the II-III loop of the α1s subunit |
| 5 | R.T. Rebbeck: In vitro interactions between the 35 C-terminus residues of the β1a subunit of DHPR and RyR1 from skeletal muscle |
| 6 | E. Wium: Identifying the skeletal muscle ryanodine receptor activation domain of triadin |
| 7 | A.D. Hanna: Multiple effects of the anthracycline daunorubicin on the cardiac ryanodine receptor |
| 8 | L.J. Holt: Grb10 knockout mice: analysis of a lean phenotype |
| 9 | D.W. Williams: The effect of suramin (a calmodulin antagonist) on the properties of the contractile apparatus of single fibres from the extensor digitorum longus (EDL) muscle of the rat |
| 10 | A. Chen: What does dysferlin do in membrane resealing? |
| 11 | F. Lemckert: The natural history of mitsugumin 53 and the membrane repair complex |
| 12 | F. Garton: An end to manual muscle fibre measurements; a validated computational method that automates the analysis of skeletal muscle fibre morphometry |
| 13 | L.B. Waddell: Improving diagnosis of rare muscular dystrophies |
| 14 | H. Tohma: Ceroid quantification in mdx muscles as a measure of oxidative damage |
| 15 | P.J. Houweling: ACTN3 genotype as a modifier of glucose metabolism |
| 16 | H. Willemse: Interactions between a variably spliced region of RyR1 and regions of the DHPR involved in skeletal excitation contraction coupling |
| 17 | David Morris. Inotropic, lusitropic and possible toxic effect of the cardio-protective agent riluzole |
| 18 | G. S. Posterino: Intrauterine growth restriction alters troponin expression and cardiac contractility |
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